Glycosylation of macrolide antibiotics in extracts of Streptomyces lividans
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چکیده
منابع مشابه
Single Streptomyces lividans K+ Channels
Basic electrophysiological properties of the KcsA K(+) channel were examined in planar lipid bilayer membranes. The channel displays open-state rectification and weakly voltage-dependent gating. Tetraethylammonium blocking affinity depends on the side of the bilayer to which the blocker is added. Addition of Na(+) to the trans chamber causes block of open-channel current, while addition to the ...
متن کاملHistone-like protein of Streptomyces lividans
A DNA-bineting protein (about lOkDa and pI>9.7) of Streptomyces lividans TK24 was purified on a denatured DNA-Cellulose column, and then on a native DNA-Cellulose column. The N-terminal amino acid sequence of this protein had high homology with those of small basic DNA-binding proteins known as histone-like proteins. Thus, this protein was designated HSI (histone-like protein of ::J.. lividans)...
متن کاملCharacterization of the Streptomyces lividans PspA response.
Phage shock protein (Psp) is induced by extracytoplasmic stress that may reduce the energy status of the cell. It is encoded in Escherichia coli by the phage shock protein regulon consisting of pspABCDE and by pspF and pspG. The phage shock protein system is highly conserved among a large number of gram-negative bacteria. However, many bacterial genomes contain only a pspA homologue but no homo...
متن کاملTwin-arginine translocation pathway in Streptomyces lividans.
The recently discovered bacterial twin-arginine translocation (Tat) pathway was investigated in Streptomyces lividans, a gram-positive organism with a high secretion capacity. The presence of one tatC and two hcf106 homologs in the S. lividans genome together with the several precursor proteins with a twin-arginine motif in their signal peptide suggested the presence of the twin-arginine transl...
متن کاملElucidation of structure of novel macrolide antibiotics produced by mutant strains of Streptomyces fradiae.
Tylosin is a 16-membered macrolide antibiotic which is produced commercially by strains of Streptomyces fradiae'•1' and is composed of a substituted lactone (tylonolide), an amino sugar (mycaminose) and two neutral sugars (mycinose, mycarose)'). Recently, a series of mutants of S. fi•adiae which are blocked in specific steps in the biosynthesis of tylosin has been described". From an analysis o...
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ژورنال
عنوان ژورنال: Antimicrobial Agents and Chemotherapy
سال: 1992
ISSN: 0066-4804,1098-6596
DOI: 10.1128/aac.36.2.348